Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,071 – 5,085 of 60,541 results

5,071

Cayman Chemical CAY10746, Purity: ≥95%, CAS: 2247240-76-0, 5 mg

A ROCK1 and ROCK2 inhibitor (IC50s = 14 and 3 nM, respectively); selective for ROCK1 and ROCK2 over PKA (IC50 = >10,000 nM) and over 387 recombinant human protein kinases in a panel of 394 kinases (IC50s = >10,000 nM for all) but does inhibit LIMK2, Aurora A, Aurora B, PKG1α, and PKG1β (IC50s = 46, 1,072, 1,239, 517, and 660 nM, respectively); inhibits phosphorylation of MYPT1 in SH-SY5Y cells at 0.1-10 µM; inhibits HUVEC migration at 1 µM; protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy; promotes high glucose-induced vessel regression in mouse retinal explants

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5,072

Medchemexpress LLC KPLH1130 | 906669-07-6 | 99.9% | 1 ML

KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. It inhibits M1 macrophage polarization by decreasing pro-inflammatory cytokines and reducing M1 phenotype markers. It prevents the decrease in mitochondrial oxygen consumption rate caused by inflammatory stimuli and improves glucose tolerance in mice fed a high-fat diet. This compound is useful for studying obesity-associated metabolic disorders and inflammatory conditions.

Inhibits M1 macrophage polarization
Decreases expression of pro-inflammatory cytokines
Reduces M1 phenotype markers (HIF-1α, iNOS)
Lowers nitric oxide (NO) production
Prevents decrease in mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli
Improves glucose tolerance in high-fat diet-fed mice
Useful for studying obesity-associated metabolic disorders
Useful for studying inflammatory conditions

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5,073

Medchemexpress LLC Gluconate sodium (D-Gluconic acid sodium salt) | 527-07-1 | ≥98.0% | 50 G

Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. It reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6) and inhibits ERK phosphorylation. It also possesses antioxidant and antiplatelet activation activities, and has demonstrated antitumor activity against colorectal cancer. Furthermore, it has been shown to improve osteoarthritis, intestinal damage, and acute lung injury.

Reduces nitric oxide and inflammatory cytokines.
Inhibits ERK phosphorylation.
Offers antioxidant and antiplatelet activation.
Demonstrates antitumor activity against colorectal cancer.
Improves osteoarthritis, intestinal damage, and acute lung injury.
Regulates hematological parameters.
Alleviates intestinal injury.

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5,074

TARGETMOL CHEMICALS INC AKBA 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM. purity: 99%

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5,075

Medchemexpress LLC HY-145804 5mg , AZD-9574 CAS:2756333-39-6 Purity:>98%

HY-145804 5mg AZD-9574 CAS: 2756333-39-6 AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD+ breast cancer and advanced solid malignancies research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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5,076

Medchemexpress LLC Incb059872 dihydrochloride | 3062683-32-0 | 99.2% | C23H36Cl2N2O3 | 10MG

INCB059872 dihydrochloride is the dihydrochloride salt of a potent, orally active, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1). Supplied for laboratory research use only, the compound is provided at high purity and has been used in preclinical studies of myeloid leukemia and epigenetic regulation.

Potent, selective LSD1 inhibition.
Orally active in preclinical models.
High chemical purity (99.18%).
Dihydrochloride salt form for improved stability.
Intended for laboratory research use only.

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5,077

TARGETMOL CHEMICALS INC SPDP 50MG

Also available in 5 mg 10 mg 25 mg 100 mg 200 mg and bulk. Please contact Fisher for quotes. SPDP is a short-chain crosslinker which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5). purity: 100%

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5,078

Cayman Chemical TPX-0022, Purity: ≥98%, CAS: 2271119-26-5, 25 mg

An inhibitor of Src, MET, and FMS kinases (IC50s = 0.12, 0.14, and 0.76 nM, respectively); inhibits the proliferation of MKN45 and SNU-5 human gastric cancer cells (IC50s = 0.2 and 0.17 nM, respectively), as well as Ba/F3 pro-B cells expressing TEL-CSF1R (IC50s = 19.3 nM); inhibits cell migration of HCC827 cells at 100 nM; inhibits tumor growth in a MKN45 mouse xenograft model at 10 and 30 mg/kg; inhibits phosphorylation of MET at Tyr1234 and Tyr1349 in the same model at 10 mg/kg

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5,079

Cayman Chemical M50054, Purity: ≥98%, CAS: 54135-60-3, 25 mg

A cell-permeable inhibitor of caspase-3 activation; blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide

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5,080

Medchemexpress LLC GNE-049 | 1936421-41-8 | 99.7% | 510.58 | 25 MG

GNE-049 is a highly potent and selective CBP inhibitor. It demonstrates inhibition of BRET and BRD4(1).

Highly potent and selective CBP inhibitor
Inhibits BRET and BRD4(1)
Excellent potency in BRET cellular assay
Inhibits MYC expression
Acceptable pharmacokinetics in multiple species
Selective for CBP/P300 over BRD4(1)

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5,081

Medchemexpress LLC Praeruptorin A | 73069-27-9 | 50 MG

Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation.

10 mg
25 mg
50 mg
100 mg

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5,082

TARGETMOL CHEMICALS INC JMS-17-2 10MG

Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 0.32 nM). purity: 98%

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5,083

Apexbio Technology LLC Nutlin-3, 5mg. Cas: 890090-75-2 MFCD: MFCD07784509. MDM2 antagonist,inhibits MDM2-p53 interaction

Nutlin-3, a tetra-substituted imidazoline, is a potent and selective small-molecule antagonist of murine double minute 2 (MDM2), which occupies the binding site of p53 in MDM2 and consequently prevent MDM2 binding to p53 leading to the disruption of the autoregulator feedback loop Other sizes are available. Please inqury us for quote.

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5,084

Selleck Chemical LLC CGS 21680 HCl 5mg

CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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5,085

Selleck Chemical LLC PF-04929113 (SNX-5422) S2656-5mg

PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM Phase 1/2

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Bioactive Small Molecules

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Medchemexpress LLC KPLH1130 | 906669-07-6 | 99.9% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Gluconate sodium (D-Gluconic acid sodium salt) | 527-07-1 | ≥98.0% | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-145804 5mg , AZD-9574 CAS:2756333-39-6 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Incb059872 dihydrochloride | 3062683-32-0 | 99.2% | C23H36Cl2N2O3 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GNE-049 | 1936421-41-8 | 99.7% | 510.58 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Praeruptorin A | 73069-27-9 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More